A pseudopotential theory for solute‐vacancy binding energies is derived for binary alloys which includes effects of solute‐solute interactions. Using this approach, small binding energies are calculated for impurity‐vacancy interactions in dilute Al&sngbnd;Cu, Al&sngbnd;Mg, Al&sngbnd;Ag, and Pb&sngbnd;In alloys in close agreement with the results of previous high‐temperature equilibrium experiments. Solute clustering is predicted by the model for higher concentrations of solute atoms in aluminum and lead.