Definition of a new entity of malignant extragonadal germ cell tumors
作者:
Jannie van Echten,
Bauke de Jong,
Richard J. Sinke,
Daniël Olde Weghuis,
Dirk Th. Sleijfer,
J. Wolter Oosterhuis,
期刊:
Genes, Chromosomes and Cancer
(WILEY Available online 1995)
卷期:
Volume 12,
issue 1
页码: 8-15
ISSN:1045-2257
年代: 1995
DOI:10.1002/gcc.2870120103
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractTwo malignant extragonadal germ cell tumors are reported, histologically classified as immature teratomas, having pseudodiploid karyotypes with complex structural rearrangements but lacking isochromosome 12p or other rearrangements involving 12p. The absence of 12p material in structural rearrangements was confirmed by chromosome painting. In the two tumors the following common chromosomal breakpoints were found: 6p21, 6p22, 6q23, and 11q13. Exactly the same chromosomal regions, 6p22::6q23 and 6p21::11q13, were involved in fusions. The two tumors belong to a new entity of extragonadal immature teratomas of adults which may be located in the retroperitoneum and posterior mediastinum and are prone to blood borne metastasis.
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