Hypertension Causes Premature Aging of Endothelial Function in Humans
作者:
Stefano Taddei,
Agostino Virdis,
Paola Mattei,
Lorenzo Ghiadoni,
Ciro Basile Fasolo,
Isabella Sudano,
Antonio Salvetti,
期刊:
Hypertension
(OVID Available online 1997)
卷期:
Volume 29,
issue 3
页码: 736-743
ISSN:0194-911X
年代: 1997
出版商: OVID
数据来源: OVID
摘要:
60 years), L-arginine was no longer effective, and indomethacin exerted a potentiating action that was positively related to advancing age. In normotensive and hypertensive humans, similar mechanisms, including dysfunction of the nitric oxide pathway and production of cyclooxygenase-dependent vasoconstrictors, cause age-related impairment of endothelium-dependent vasodilation, and only their earlier appearance characterizes hypertensive disease. Thus, the endothelial dysfunction that occurs in hypertension seems to represent an accelerated form of dysfunction that occurs in aging. (Hypertension. 1997;29:736-743.)
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