Metallopeptides — from Drug Discovery to Catalysis
作者:
Li‐June Ming,
期刊:
Journal of the Chinese Chemical Society
(WILEY Available online 2010)
卷期:
Volume 57,
issue 3A
页码: 285-299
ISSN:0009-4536
年代: 2010
DOI:10.1002/jccs.201000043
出版商: WILEY‐VCH Verlag
关键词: Alzheimer's disease;Antibiotics;Antimicrobial;Bacitracin;β‐Amyloid;Catechol oxidase;Copper;Histatin;Metalloantibiotics;Metallopeptide;NMR;Oxidation;Paramagnetic
数据来源: WILEY
摘要:
AbstractOligopeptides are involved in diverse biological activities, including neurotransmission and antibiotic. Many natural‐occurring peptides and peptide‐ketide hybrids exhibit specific biological activities and chemical reactivities upon binding with certain metal ions, such as divalent metal‐binding antibiotic bacitracin and anticancer Fe/Cu‐bleomycin. There are also numerous synthetic peptides designed to bind metal ions to exhibit wide range of physical properties and chemical and biological activities. In this review we summarize the background and discuss our research on metal binding properties, structures, and chemical reactivities of three metallopeptides, the bacterial antibiotic bacitracin, the Alzheimer's disease‐related β‐amyloid, and the salivary antimicrobial histatin. Despite their different structures and biological functions, the Cu2+complexes of these peptides exhibit significant activities toward catechol oxidation and phenol hydroxylation. However, the mechanisms of the oxidative reactions among these three Cu‐peptides seem to be distinctively different. Our current understanding about the structure‐bioactivity relationship and chemical reactivities as well as implications in drug discovery of these peptides are s
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