AbstractA rapid, specific and reliable gas chromatographic assay procedure for Nifedipine in plasma has been developed. With a single‐step solvent extraction, and electron capture detection, the method is sensitive to 0.5 ng/mL of plasma and the standard curve is linear from 0.5 to 500 ng/mL. Samples are protected from light to prevent formation of photodecomposition products. The method has been used to monitor drug concentrations in patients receiving therapeutic dose