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Originalarbeiten: Human Serum Albumin Microspheres for Lung Imaging – Preparation and Evaluation

 

作者: Aleyamma Raju,   R. Mani,   K. D. Divekar,   D. V. S. Narasimhan,   A. D. Rahalkar,   R. Lal,   Sundararajan,   P. Kotrappa,   R. S. Mani,  

 

期刊: Isotopenpraxis Isotopes in Environmental and Health Studies  （Taylor Available online 1978）
卷期: Volume 14, issue 2  

页码: 57-61

 

ISSN:0021-1915

 

年代: 1978

 

DOI:10.1080/10256017808544145

 

出版商: Taylor & Francis Group

 

关键词: aerosol generators;albumins;heat treatment;isomeric nuclei;labelled;lung clearance;lungs;mice;microspheres;particle size;performance testing;protein denaturation;radiopharmaceuticals;rats;scintiscanning;technetium 99;uptake

 

数据来源: Taylor

 

摘要:

Preparation of human serum albumin microspheres of well defined particle size distribution using a spinning disc aerosol generator has been investigated by the authors. A set up is described for bulk preparation of microspheres suitable for lung imaging. A simple procedure for denaturation of the microspheres by direct oven heating has been standardised. Methods for Tc99mlabelling of these microspheres with high radiochemical yield and purity have been studied. Uptake and clearance of the labelled microspheres have been followed in experimental animals. Histopathological examination has been carried out to confirm biodegradability and safety of the microspheres. The microspheres have shown excellent lung uptake and have been found to be very safe for administration.

 

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