A simple, practical, and economical procedure had been developed to prepare novel C18 ether-bond reversed phase packing. A soft and long C18alkyl chain was coupled onto silica (Sinopak-S, particle size d = 5μm, pore diameter Dp=11nm, and surface area s=170m2/g) with γ-glycidoxypropyltrimethoxysilane as a coupling agent. Characterization of prepared packing was carried out with elemental analysis and solid-state [13]C NMR. Chromatographic evaluation indicates that its reversed phase behavior was similar to ordinary ODS.