Crescentic Glomerulonephritis as Renal Cause of Acute Renal Failure
作者:
GrcevskaL.,
PolenakovicM.,
期刊:
Renal Failure
(Taylor Available online 1995)
卷期:
Volume 17,
issue 5
页码: 595-604
ISSN:0886-022X
年代: 1995
DOI:10.1080/0886022X.1995.12098271
出版商: Taylor&Francis
关键词: Acute renal failure;Crescentic glomerulonephritis;Plasmapheresis
数据来源: Taylor
摘要:
ABSTRACTOver a period of 5 years, we observed 28 patients with biopsy-proven crescentic glomerulonephritis. Four of these patients were ANCA associated (pauci immune), I had anti-glomerular basement membrane antibodies (anti-GBM), and the other 23 cases had immune complex form (22 poststreptococcal and I poststaphylococcal). Acute renal failure as a main clinical feature was found in 11/28 (35.7%), all with more than 80% crescents, including all ANCA-associated cases, anti-GBM form, and the patient with poststaphylococcal form. Using“pulse”therapy with methylprednisolone, cyclophosphamide, and plasmapheresis, renal function was improved in 5/11 (45.4%), diuresis started, and end-stage renal disease was delayed. The therapy was continued orally with steroids and cyclophosphamide. The second attack of oligoanuria developed after a period of 6-12 months without improvement after the therapy used previously (during the first attack), and it was necessary to begin chronic hemodialysis treatment.
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