Angiotensin (1–7) is an antagonist at the type 1 angiotensin II receptor
作者:
Julie Mahon,
Richard Carr,
Alexander Nicol,
Ian Henderson,
期刊:
Journal of Hypertension
(OVID Available online 1994)
卷期:
Volume 12,
issue 12
页码: 1377-1382
ISSN:0263-6352
年代: 1994
出版商: OVID
关键词: Losartan;angiotensin II;angiotensin(1–7) receptor;rabbit aorta, hypertension
数据来源: OVID
摘要:
ObjectiveThe present study investigated the antagonism of the amino-terminal heptapeptide fragment of angiotensin II {[des-Phe8]-angiotensin II; Ang(1–7)} to angiotensin II (Ang II) both in vitro in rabbit aortae and in vivo in rats.Methods and resultsIn rabbit isolated endothelium intact aortic rings Ang(1–7) caused a concentration-related rightward displacement of the Ang II curve and depressed the maximum response to Ang II. By applying the data to a Schild plot an apparent pA2 of 5.5 was calculated. This depression of maximum response could be reversed by co-incubation of Ang(1–7) with the competitive angiotensin antagonist losartan. Ang(1–7) had no effect on the contractile responses of several other agonists. Intravenous infusion of 10 or 100 μg/kg per min Ang(1–7) had no effect on the resting blood pressure in the anaesthetized rat but inhibited Ang II-induced pressor responses.ConclusionThe present results show that Ang(1–7) is a specific non-competitive antagonist of Ang II at type 1 angiotensin II receptors.
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