Effects of Phenobarbital on Cerebral Blood Flow and Metabolism in Young and Aged Rats
作者:
Verna Baughman,
William Hoffman,
David Miletich,
Ronald Albrecht,
期刊:
Anesthesiology
(OVID Available online 1986)
卷期:
Volume 65,
issue 5
页码: 500-505
ISSN:0003-3022
年代: 1986
出版商: OVID
关键词: Age factors.;Anesthetics, intravenous: phenobarbital.;Brain: blood flow; metabolism.
数据来源: OVID
摘要:
The cerebrovascular and cerebral metabolic chancges produced by intraperitoneal injection of phenobarbital (50, 150, and 250 mg/kg) were studied in young adult (6-month) and senescent (28-month) Wistar rats. Cerebral blood flow (CBF) was measured using radioactive microspheres and cerebral oxygen consumption (CMRO2) was obtained by multiplying cortex CBF by the arterial-sagittal sinus oxygen content difference. Control values for blood pressure, blood gas tensions, CBF, and CMRo2were similar in the young and aged animals during 70% N2O/30% O2. Intraperitoneal phenobarbital produced dose-dependent decreases in CBF with no significant difference between young and aged rats at each phenobarbital dose. At the highest phenobarbital dose (250 mg/kg) CBF was reduced by 49% in the young rats and 52% in the aged rats (P> 0.10). CMRo2was also depressed in a dose-dependent fashion in both young and aged animals with each phenobarbital dose. However, the decrease produced by the highest phenobarbital dose was significantly greater in the aged rats (55%) than the young rats (43%,P< 0.05), even though the EEG was isoelectric in both groups. The difference in CMRo2between youngversusaged rats at a time when the EEG is isoelectric suggests that high-dose phenobarbital may depress nonelectrical cerebral metabolic processes more in aged rats.
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