Cisplatin‐ based chemotherapy of epithelial ovarian cancer
作者:
Howard D. Homesley,
期刊:
Journal of Surgical Oncology
(WILEY Available online 1989)
卷期:
Volume 42,
issue S1
页码: 21-25
ISSN:0022-4790
年代: 1989
DOI:10.1002/jso.2930420506
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: ovary;carcinoma;cisplatin
数据来源: WILEY
摘要:
AbstractThe current International Federation of Gynecology and Obstetrics (FIGO) staging system, independent prognostic factors, and review of the Gynecologic Oncology Group (GOG) studies in epithelial ovarian carcinoma are presented. With this background, approaches using cisplatin‐ based regimens in ovarian carcinoma trials are outlined. A short three‐ course cycle of cisplatin plus cyclophosphamide is currently being compared with intraperitoneal phosphorus 32 in high‐ risk stage I‐ II patients. In optimal stage III patients, cisplatin plus cyclophosphamide without doxorubicin in a recent GOG study was as effective as all three drugs. In suboptimal stage III patients, a current dose‐ intensity study is comparing 100 mg/m2cisplatin plus 1 g/m2cyclophosphamide for four courses to the previously studied eight courses of 50 mg/m2cisplatin and 500 mg/m2cyclophosphamide. Trials are also under way to determine the utility of intraperitoneal cisplatin in a phase III study of optimal stage III as first‐ line therapy and another study is active for second‐
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