Lack of benefit of allopurinol in duchenne dystrophy
作者:
Jerry R. Mendell,
David O. Wiechers,
期刊:
Muscle&Nerve
(WILEY Available online 1979)
卷期:
Volume 2,
issue 1
页码: 53-56
ISSN:0148-639X
年代: 1979
DOI:10.1002/mus.880020108
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractA double‐blind, controlled study was conducted to assess the effects of allopurinol on Duchenne muscular dystrophy. Six patients—three treated with allopurinol and three given a placebo—were followed up for one year and were evaluated by functional and manual muscle testing as well as by determination of serum creatine kinase (CK) levels. Patients in both the allopurinol‐treated group and the placebo group deteriorated at varying rates without evidence of therapeutic benefit. To exclude the possibility of error attributable to small sample size, all six patients were treated with allopurinol for an additional eight‐week period. Muscle strength continued to deteriorate during this phase of
点击下载:
PDF
(289KB)
返 回