Ochronosis in Black South Africans Who Used Skin Lighteners
作者:
James Phillips,
Charles Isaacson,
Hilary Carman,
期刊:
The American Journal of Dermatopathology
(OVID Available online 1986)
卷期:
Volume 8,
issue 1
页码: 14-21
ISSN:0193-1091
年代: 1986
出版商: OVID
数据来源: OVID
摘要:
Skin-lightening preparations containing hydroquinone are used extensively by black South Africans. In some instances these preparations produce severe and irreversible cutaneous damage. Clinically, the deleterious effects begin with darkening and coarsening of the skin, followed by a hyperpigmented papular condition. Histologically, there is increased basophilia of the collagen, followed by the formation of yellow fibers. These yellow fibers swell and break down to form an amorphous eosinophilic material. Electron microscopy shows that the changes arise from a breakdown of normal collagen.
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