首页   按字顺浏览 期刊浏览 卷期浏览 Prospective Study on Captopril Renography in Hypertensive Patients
Prospective Study on Captopril Renography in Hypertensive Patients

 

作者: Dario Roccatello,   Giuseppe Picciotto,   Claudio Rabbia,   Marco Pozzato,   Pier Giuseppe De Filippi,   Giuseppe Piccoli,  

 

期刊: American Journal of Nephrology  (Karger Available online 1992)
卷期: Volume 12, issue 6  

页码: 406-411

 

ISSN:0250-8095

 

年代: 1992

 

DOI:10.1159/000168490

 

出版商: S. Karger AG

 

关键词: ACE-inhibition;Captopril renography;Renovascular hypertension;Hypertension;Percutaneous transluminal renal angioplasty;Revascularization

 

数据来源: Karger

 

摘要:

Six hundred and sixty-seven hypertensive patients were analyzed by captopril-enhanced scintigraphy. If time to reach maximal activity (Tmax) was ≧ 5 min using 99mTc-diethylenetriaminepentaacetic acid (DTPA) or ≧ 3 min with 123I-oiodohippurate (OIH) and 99mTc-mercaptoacetyltriglycine (MAG3) and washout time ≧ 15 min, a control study with nifedipine was performed. If the difference between Tmax under captopril and nifedipine premedication was ≧ 5 min with 99mTc-DTPA or ≧ 3 min with 123I-OIH and 99mTc-MAG3, the renogram was defined highly suggestive of renovascular hypertension. In the evaluation of bilateral abnormalities an additional parameter was considered, i.e. the presence of functional asymmetry of the emuntories susceptible of partial reversal in the control study under nifedipine. Based on these criteria, 58 out of 667 (8.7%) scintigrams were found to be abnormal. Thirty-five of these 58 patients and 32 of the remaining 609 scintigraphically negative cases underwent additional arteriographic examination. A renal vascular stenosis ≧ 50% was found in 33 out of 35 (94.2%) patients with positive scintigraphy and in 3 out of 32 patients with negative scintigraphy. By examining results of the 67 patients undergoing arteriography, the sensitivity of captopril-enhanced scintigraphy was estimated to be 91.6 %, with a specificity of 9 3.5 %, an accuracy of 92.5 %, and predictive values of a positive or negative result of 94.2 and 90.6%, respectively. By restricting analysis to bilateral stenosis, sensitivity was found to be 76.9%. Postexamination of 16 patients undergoing revascularization by surgery or percutaenous transluminal renal angioplasty reflected the expected results with a substantial shortening in Tmax and T75 in the respo

 

点击下载:  PDF (1224KB)



返 回