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Spectrophotometric Study of Mithramycin Complexes with Cu(II), Fe(III) and Tb(III)

 

作者: M.A. Pereira,   T.L. de Figueiredo,   C. Demicheli,  

 

期刊: Analytical Letters  （Taylor Available online 1997）
卷期: Volume 30, issue 14  

页码: 2555-2563

 

ISSN:0003-2719

 

年代: 1997

 

DOI:10.1080/00032719708001765

 

出版商: Taylor & Francis Group

 

关键词: Mithramycin;Metal complexes;Stability constants;Spectrometry

 

数据来源: Taylor

 

摘要:

The coordination of the anticancer drug mithramycin to Tb(III), Fe(III) and Cu(II) was studied in aqueous solution using absorption measurements. The stability constants were calculated from equilibrium competition experiments by means of the SQUAD program. For both first ions, the competitor was oxalic acid and for the latter the competitor was the Cu(II) ions. Cu(II) at pH 7.5, Fe(III) at pH 3.5 and Tb(III) at pH 5.5 formed respectively 1:2, 1:3 and 1:4 metal-to-ligand species.

 

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