Retinoid‐Induced Potentiation of Epidermal Growth Factor Mitogenic Effect on Corneal Endothelial Cells
作者:
Didier Junquéro,
Guy Modat,
Claude Coquelet,
Claude Bonne,
期刊:
Cornea
(OVID Available online 1990)
卷期:
Volume 9,
issue 1
页码: 41-44
ISSN:0277-3740
年代: 1990
出版商: OVID
关键词: Retinoids;Retinoic acid;CBS-211 A;Epidermal growth factor;Corneal endothelium;Cell culture;Proliferation
数据来源: OVID
摘要:
Epidermal growth factor (EGF) is mitogenic for bovine corneal endothelial cells in culture. Pretreatment with either retinoic acid or the synthetic analog CBS-211 A ((E)-4-[2-(2-isopropyl-5-thienyl)propenyl]benzoic acid) at 10-8-10-6M enhanced the EGF effect. This potentiating effect of retinoids contrasts with their intrinsic activity, which results in cell growth inhibition in the absence of growth factor. The present data emphasize the previously reported beneficial effect of retinoic acid on corneal endothelium wound healing. This effect could be related to the potentiation of endogenous growth factors and further underlines the importance of retinoids in the medical treatment of corneal endothelial lesions.
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