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Angiotensin I-Converting Enzyme Activity in Rats with Carbon Tetrachloride-Induced Acute Renal Failure

 

作者: PedrazaJose,   CruzCristino,   HernandezRogelio,   SantanaThalia,   ArevaloAna Elena,   GonzalezLaura,   TapiaEdilia,   PeñaJosÉCarlos,   PanduroArturo,  

 

期刊: Renal Failure  (Taylor Available online 1993)
卷期: Volume 15, issue 1  

页码: 19-26

 

ISSN:0886-022X

 

年代: 1993

 

DOI:10.3109/08860229309065567

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

The angiotensin I-converting enzyme (ACE) activity was measured in urine, serum, and tissues from rats with carbon tetrachloride (CCl4)-induced acute renal failure on days 1, 2, 3, and 7 after CCl4administration. Serum ACE increased on days 1 to 3. Heart, lung, small intestine, brain, and testis ACE decreased, whereas kidney and liver ACE remained unchanged. Urine ACE activity increased from day 1 to day 3. Our data suggest that the increase in serum ACE may be secondary to the ACE release from the damaged tissues, and that the urine ACE increase may be due to the kidney proximal tubule damage. This work supports the contention that an increase in urine ACE may be an indicator of damage to the proximal tubule.

 

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