Genetic manipulation of the shikimate pathway to overproduce aromatic amino acids
作者:
K. Venkat,
K. Backman,
R.T. Hatch,
期刊:
Food Biotechnology
(Taylor Available online 1990)
卷期:
Volume 4,
issue 1
页码: 547-547
ISSN:0890-5436
年代: 1990
DOI:10.1080/08905439009549768
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
In this paper, we describe a successful approach to genetically modify the shikimate pathway ofE. colito overproduce aromatic amino acids. Every gene in the entire pathway was manipulated and its effect was examined. Based on this analysis, an optimum combination of genes and their expression levels were arrived at to maximize aromatic amino acid production. Feedback repression/inhibition effects are essentially neutralized by this approach.
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