Modulation of Cervical Carcinogenesis by Tamoxifen in a Mouse Model System
作者:
Archana Sengupta,
Santi Dutta,
Ranjit Mallick,
期刊:
Oncology
(Karger Available online 1991)
卷期:
Volume 48,
issue 3
页码: 258-261
ISSN:0030-2414
年代: 1991
DOI:10.1159/000226938
出版商: S. Karger AG
关键词: Cervical carcinogenesis;Tamoxifen;Latent period
数据来源: Karger
摘要:
Insertion of cotton thread impregnated with beeswax and 20-methylcholanthrene (carcinogen) inside the canal of the uterine cervix in intact and oophorectomized mice results in the expression of dysplasia and carcinoma of the cervical epithelium. Based upon the experimental cervical carcinogenesis observed in this mouse model system, the present study shows distinctly the modulatory effect of tamoxifen on the incidence of cervical carcinoma. Besides this, tamoxifen significantly lenghthens the latent period for both dysplasia and carcinoma in the cervical epithelium. This manifestation was found more marked in oophorectomized animals.
点击下载:
PDF
(1367KB)
返 回