In vivometabolic activity of a putative circadian oscillator, the rat suprachiasmatic nucleus
作者:
W. J. Schwartz,
L. C. Davidsen,
C. B. Smith,
期刊:
Journal of Comparative Neurology
(WILEY Available online 1980)
卷期:
Volume 189,
issue 1
页码: 157-167
ISSN:0092-7317
年代: 1980
DOI:10.1002/cne.901890109
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: suprachiasmatic nucleus;circadian rhythm;2‐deoxy‐D‐[14C]glucose
数据来源: WILEY
摘要:
AbstractThe suprachiasmatic nucleus (SCN) has been proposed as a site for an endogenous circadian oscillator in mammals, since lesions of the nucleus abolish a wide spectrum of overt circadian rhythms. To demonstrate that a directly measurable property of the SCN itself in intact (unlesioned) animals is affected by environmental light and exhibits circadian rhythmicity, we used the autoradiographic 2‐deoxy‐D‐[14C]glucose method to determine glucose utilization of rat SCN under a variety of lighting conditions. Our experiments indicate an important role for the SCN in circadian rhythm organization, and we believe the deoxyglucose method will prove useful as a tool for better understanding the functions and mechanisms of circadian c
点击下载:
PDF
(1319KB)
返 回