Hydrogen peroxide‐induced motoneuron apoptosis is prevented by poly ADP ribosyl synthetase inhibitors
作者:
Bruno Hivert,
Catherine Cerruti,
William Camu,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 8
页码: 1835-1838
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: ALS;Apoptosis;Poly ADP ribosyl synthetase;Motoneuron
数据来源: OVID
摘要:
THE impact of oxidative stress (H2O2) was observed using purified rat motoneuron cultures and H2O2-induced dose-dependent motoneuron death was demonstrated. The apoptotic characteristics of cell death were studied morphologically and using the TUNEL technique. This H2O2-induced motoneuron death was inhibited by the poly ADP ribosyl synthetase (PARS) inhibitors benzamide and nicotinamide. These findings suggest the potential utility of PARS inhibitors in the treatment of neurodegenerative disorders such as amyotrophic lateral sclerosis, in which oxidative stress has been suspected to play an important etiopathogenic role.
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