Antidepressant and Anxiolytic Profiles of E-10-Hydroxynortriptyline on Electrocorticograms of Rats
作者:
Conny Nordin,
Frans Krijzer,
期刊:
Neuropsychobiology
(Karger Available online 1996)
卷期:
Volume 34,
issue 1
页码: 44-48
ISSN:0302-282X
年代: 1996
DOI:10.1159/000119290
出版商: S. Karger AG
关键词: Automated drug classification;Visual drug classification;Electrocorticogram;E-10-hydroxynortriptyline;Vigilance control
数据来源: Karger
摘要:
Electrocorticograms of rats were recorded after administration of increasing doses of the major metabolite of nortriptyline (NT), E-10-hydroxynortriptyline (E-10-OH-NT). The results were compared with those of NT administration. In visual as well as computerized evaluations, E-10-OH-NT demonstrated clear antidepressant properties, thus confirming previous experiments in depressed patients. There is some evidence that E-10-OH-NT also has an anxiolytic profile. The results with the parent drug NT were not so pronounced. Since E-10-OH-NT has been shown to be devoid of side effects when previously administered to humans, this substance is clearly to be considered of interest for potential development into a new antidepressant. Whether or not the anxiolytic profile is of clinical interest needs to be investigated further.
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