Studies on the discontinuousN-oxidation of trimethylamine among Jordanian, Ecuadorian and New Guinean populations
作者:
S C Mitchell,
A Q Zhang,
T Barrett,
R Ayesh,
R L Smith,
期刊:
Pharmacogenetics
(OVID Available online 1997)
卷期:
Volume 7,
issue 1
页码: 45-50
ISSN:0960-314X
年代: 1997
出版商: OVID
关键词: trimethylamine;N-oxidation;populations;Jordanian;Ecuadorian;New Guinean
数据来源: OVID
摘要:
Whilst the majority of individuals within a British white population are able to convert greater than 90% of their dietary-derived trimethylamine to its N-oxide, outliers exist who show varying degrees of impairment. Such individuals excrete unoxidized trimethylamine in their urine and, if sufficiently compromised, may experience malodour problems (Fish- Odour Syndrome). Little information concerning this polymorphicN-oxidation process is available in other ethnic groups and the present study explores Jordanian, Ecuadorian and New Guinean populations. Subjects with a relative deficiency inN-oxidation were found in all three groups, with 1.7% (2/116) Jordanian, 3.8% (3/80) Ecuadorian and 11.0% (11/100) New Guinean excreting 80% or less of their total trimethylamine as theN-oxide. Two subjects from the Ecuadorian population (4% and 33% total trimethylamine as theN-oxide) exhibited frank trimethylaminuria. These observations suggest that a compromised ability to N-oxidize trimethylamine is detectable in several ethnic groups and that this polymorphic phenomenon may have a widespread existence.
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