COMPARISON OF MOUSE STRAINS FOR SUSCEPTIBILITY TO STYRENE-INDUCED HEPATOTOXICITY AND PNEUMOTOXICITY
作者:
GaryP. Carlson,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1997)
卷期:
Volume 51,
issue 2
页码: 177-187
ISSN:0098-4108
年代: 1997
DOI:10.1080/00984109708984020
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Styrene is known to cause both hepatotoxicity and pneumotoxicity in mice. Strain differ ences have been reported by other investigators suggesting that Swiss mice are less suscep tible than non-Swiss mice to styrene-induced liver damage. In this study, A/I and C57BL/6 mice were found to be similar to non-Swiss albino (NSA) mice in susceptibility whereas CD-1 (Swiss) mice were more resistant to hepatotoxicity as assessed by serum sorbitol de hydrogenase levels and pneumotoxicity as determined by gamma-glutamyltranspeptidase and lactate dehydrogenase measurements in bronchoalveolar lavage fluid. Styrene was hepatotoxic in CD-I mice treated with pyridine to induce CYP2E1. CYP2EI apoprotein levels and p-nitrophenol hydroxylase activities in control and pyridine-induced mice were similar in the two strains. Hepatic and pulmonary microsomal preparations from both strains metabolized styrene to styrene oxide at similar rates. CD-1 mice were as susceptible as the NSA mice to the effects of styrene oxide. The data suggest that there are no differ ences in the bioactivation of styrene to styrene oxide or innate susceptibility to the active metabolite that would account for the differences between the CD-1 and NSA mice.
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