Mediastinal mass in acute lymphoblastic leukemia
作者:
Robert R. Chilcote,
Peter Coccia,
Harland N. Sather,
Leslie L. Robison,
Robert L. Baehner,
Mark E. Nesbit,
Denman Hammond,
期刊:
Medical and Pediatric Oncology
(WILEY Available online 1984)
卷期:
Volume 12,
issue 1
页码: 9-16
ISSN:0098-1532
年代: 1984
DOI:10.1002/mpo.2950120105
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: mediastinal mass;acute lymphoblastic leukemia;prognosis
数据来源: WILEY
摘要:
AbstractPatients with acute lymphoblastic leukemia who have a mediastinal mass at the time of diagnosis are said to have a poor prognosis. However, many factors which may not be independent contribute to the success of treatment. We compared the disease characteristics and results of therapy in children having large mediastinal masses and lymphoblastic leukemia without mediastinal mass. Patients with a mediastinal mass had less evidence of marrow failure but were burdened with considerably more leukemic cells as measured by peripheral blood white count and extent of lymphadenopathy. Since the presence of mediastinal mass was strongly associated with these and other poor prognostic characteristics, we used multivariate techniques to determine which characteristics were independently associated with an increased risk for relapse. White count, extent of lymphadenopathy, age, and sex were significant predictors of early relapse, but when controlled for these variables the presence of a mass did not predict prognosis.
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