Allopurinol Influences Aminophenazone Elimination
作者:
Michael Barry,
John Feely,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 1990)
卷期:
Volume 19,
issue 2
页码: 167-169
ISSN:0312-5963
年代: 1990
出版商: ADIS
数据来源: ADIS
摘要:
The authors observed an interaction between allopurinol and both theophylline and warfarin in 2 patients. To determine the possible effect of allopurinol on hepatic oxidative metabolism a [14C]-aminophenazone (aminopyrine) breath test was performed before and during treatment with allopurinol 100mg daily in 5 patients with hyperuricaemia. Allopurinol prolonged the [14CO2]-aminophenazone half-life from 72 ± 13 to 104 ± 16 minutes (mean ± SEM, p < 0.05). It is possible that allopurinol may produce clinically significant drug interactions through an inhibitory effect not only on xanthine oxidase metabolism but also on oxidative metabolism.
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