Effect of Single and Multidose Cephradine Prophylaxis on Infectious Morbidity of Vaginal Hysterectomy
作者:
JACK MENDELSON,
JOSEPH PORTNOY,
JEAN DE SAINT VICTOR,
MORRIE GELFAND,
期刊:
Obstetrics & Gynecology
(OVID Available online 1979)
卷期:
Volume 53,
issue 1
页码: 31-35
ISSN:0029-7844
年代: 1979
出版商: OVID
数据来源: OVID
摘要:
The administration of cephradine prophylactically to patients who were undergoing vaginal hysterectomies resulted in a marked and significant reduction in the incidence of postoperative infections when compared to a placebo group. Cephradine was the cephalosporin studied because of its unique pharmacodynamic properties, which result in high uterine tissue levels. The protective effect was similar whether I g was given preoperatively followed by 500 mg IV q. 6 hours for 4 doses, or a single dose of 2 g IV given approximately 1 hour before surgery. Uterine tissue and serum levels of antibiotic were high and correlated with the degree of protection noted.
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