The peculiarities of potential barrier formation at the interface of organic photosensitive films (OPF) with metals and inorganic semiconductors (IS) are analyzed. The basic attention is given to the effect of an adsorption of oxygen, polymorphic modifications and processes of polarization arising due to the caption of nonequilibrium charge carriers in contact area of a space charge. In view of this the basic reasons for low efficiency of a solar energy conversion and possibility of their practical use are analyzed.