ENANTIORECOGNITION MECHANISMS FOR DERIVATIZED CELLULOSE UNDER REVERSED PHASE CONDITIONS
作者:
Hong Ding,
Nelu Grinberg,
Richard Thompson,
Dean Ellison,
期刊:
Journal of Liquid Chromatography & Related Technologies
(Taylor Available online 2000)
卷期:
Volume 23,
issue 17
页码: 2641-2651
ISSN:1082-6076
年代: 2000
DOI:10.1081/JLC-100101823
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The chiral recognition mechanism for a derivatized polysaccharide chiral stationary phase (CSP) under reversed phase conditions was investigated (Chiralcel OJ-R). While enantiorecognition mechanisms have been proposed for these types of phases under normal phase conditions, it is unlikely that they would apply to reversed phase conditions due to the high polarity of the eluent. Indandiol was utilized as the main probe. The effect of organic modifier, eluent anion, and temperature on enantioselectivity for indandiol was determined. Additionally, a number of structurally related probes were also investigated to define the role of various functional groups on enantioselectivity.
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