Epidemiologic analysis of gene‐environment interaction in twins
作者:
Ruth Ottman,
期刊:
Genetic Epidemiology
(WILEY Available online 1994)
卷期:
Volume 11,
issue 1
页码: 75-86
ISSN:0741-0395
年代: 1994
DOI:10.1002/gepi.1370110108
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: epidemiology;genetics;twins;gene‐environment interaction
数据来源: WILEY
摘要:
AbstractOur aim was to develop a simple method for testing gene‐environment interaction in twin data ascertained through affected twins (probands), with known exposure status of both cotwins. To this end we derived formulae for two epidemiologic measures, as a function of prevalence of an exposure and genotype, and disease risk conditional on exposure and genotype: (1) relative risk of disease in exposed vs. unexposed cotwins, stratified by zygosity and proband exposure status (RRE), and (2) relative risk of disease in MZ vs. DZ cotwins, stratified by exposure status of proband and cotwin (RRZ). Then we investigated the behavior of these two measures under different assumptions about the relations between exposure and genotype in terms of their effect on disease risk. If an exposure has a different effect in the presence vs. absence of the genotype, RREdiffers between MZ and DZ cotwins. Similarly, if a genotype has a different effect in exposed vs. unexposed persons, RRZdiffers between exposed and unexposed cotwins. However, large differences in RREbetween MZ and DZ cotwins, or large differences in RRZbetween exposed and unexposed cotwins, do not occur except under very extreme conditions, such as a genotype that increases disease risk in exposed individuals, and has a protective effect in unexposed individuals. These results suggest that power to detect gene‐environment interaction is limited with this approach. Conversely, if large differences in RREor RRZare observed, they are likely to reflect strong gene‐environment interaction. © 1994 Wiley‐L
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