Chemoprevention of upper aerodigestive tract cancers: A report of the third upper aerodigestive cancer task force workshop
作者:
Scott M. Lippman,
Jin S. Lee,
Reuben Lotan,
Waun K. Hong,
期刊:
Head&Neck
(WILEY Available online 1990)
卷期:
Volume 12,
issue 1
页码: 5-20
ISSN:1043-3074
年代: 1990
DOI:10.1002/hed.2880120103
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractThe National Cancer Institute Organ Systems Program‐sponsored Upper Aerodigestive Cancer Task Force workshops are specifically designed to enhance interactions between basic science and clinical investigators and between academic institutions and the community, and ultimately will contribute to more expeditious clinical advances. The third workshop in this series focused on the rapidly expanding area of chemoprevention of upper aerodigestive epithelial cancers. The first two sessions were devoted to discussion of in vitro and animal‐model data documenting the multistep process of squamous differentiation and carcinogenesis, associated molecular and biochemical alterations, and modulation by chemopreventive agents. Animal‐model studies have identified several promising chernopreventive agents and synergistic combinations for clinical trial. The last two sessions reviewed nutritional epidemiology, major methodologic issues of large intervention studies, and the novel concept of biologic markers as intermediate endpoints for chemoprevention t
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