Case ReportFamilial Chronic Mucocutaneous Candidiasis Complicated by Deep Candida Infection
作者:
MARC GERMAIN,
MARIE GOURDEAU,
JACQUES HÉBERT,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1994)
卷期:
Volume 307,
issue 4
页码: 282-283
ISSN:0002-9629
年代: 1994
出版商: OVID
关键词: Candidiasis;Chronic mucocutaneous;Familial;Meningitis
数据来源: OVID
摘要:
Chronic mucocutaneous candidiasis (CMC) is usually characterized by onset in childhood and is almost never complicated by deep fungal infection. The authors report two cases of fatal Candida meningitis in patients who suffered from mild, adult-onset CMC. The pedigrees suggest an autosomal recessive disorder. In the index cases and in a symptomatic sibling, the immunologic work-up showed a specific cellular deficit as opposed toCandida albicans, as is typical of other forms of CMC. Both families were of French Canadian descent and originated from eastern Quebec. Three other cases of primary Candida meningitis in patients of the same ethnic origin are also reported and reviewed. It is suggested that these cases may represent a variant of familial adult-onset CMC, in which there is a striking predisposition to deep infection.
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