SummaryA case of anuria following administration of Irgapyrin is described.The patient died despite extensive use of peritoneal dialysis. The benefits and dangers of this method of extrarenal epuration are discussed.The poor prognosis of this nephropathy could be foretold by analysis of the different renal clearances measured.The renal lesions observed in this case seem to have followed a prolonged period of renal ischemia.Acute arterial hyalinosis was noted in several organs. These changes are very similar to those elicited by experimental renal failure, and are probably caused by the same mechanism.