The compostion of 142 calculi from Sudan, Thailand, Indonesia and Saudi Arabia has been determined by qualitative and quantitative chemical analysis. Calcium oxalate was the commonest constituent of both kidney and bladder stones, followed by magnesium ammonium phosphate, ammonium acid urate, calcium phosphate, uric acid and cystine in that order. Calcium oxalate was also the main constituent of the nucleus of most kidney and bladder stones, calcium phosphate, magnesium ammonium phosphate, and ammonium acid urate occurring most frequently in the outer layers of the stones. Most endemic bladder stones appear to originate as aggregates of calcium oxalate crystals in the kidney, which subsequently descend to the bladder, where they may acquire secondary deposits of calcium phosphate, magnesium ammonium phosphate or ammonium acid urate.