Amplification of cellular oncogenes: A predictor of clinical outcome in human cancer
作者:
Manfred Schwab,
Lukas C. Amler,
期刊:
Genes, Chromosomes and Cancer
(WILEY Available online 1990)
卷期:
Volume 1,
issue 3
页码: 181-193
ISSN:1045-2257
年代: 1990
DOI:10.1002/gcc.2870010302
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractIncreased dosage of cellular oncogenes resulting from amplification of DNA is a frequent genetic abnormality of tumor cells and the study of oncogene amplification has been paradigmatic for the usefulness of molecular genetic research in clinical oncology. Certain types of human tumors carry an amplified cellular oncogene at frequencies of up to 50–60%. Human neuroblastoma has been prototypic for the importance of oncogene amplification in tumorigenesis, and evidence is emerging that amplification may be an early event involved in a more malignant form of this cancer. It is unclear at which stage amplification plays a role in other cancers. Amplification of cellular oncogenes is a good predictor of clinical outcome in some human malignancie
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