Emergence of immunoreactivities for phosphorylated tau and amyloid‐β protein in chronic stage of fluid percussion injury in rat brain
作者:
Shigeru Hoshino,
Akira Tamaoka,
Masayasu Takahashi,
Shiro Kobayashi,
Tetsuya Furukawa,
Yoshiharu Oaki,
Osamu Mori,
Sayoko Matsuno,
Shin'ichi Shoji,
Miwa Inomata,
Akira Teramoto,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 8
页码: 1879-1883
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Alzheimer's disease;Amyloid-β protein;Brain injury;Rat;Tau
数据来源: OVID
摘要:
HEAD injury is one of the potential environmental factors in Alzheimer's disease (AD). To study the chronic stage of concussive brain injury, histological analyses were performed 2–6 months after right lateral fluid percussion (FP) brain injury (3.6–4.8 atm) in rats. Six months after injury, numerous normal-looking neurons in the telencephalon and brain stem were immunoreactive with either antibody to phosphorylated tau or with four antibodies to β-amyloid protein. Neuronal counts in the cortices were gradually decreased after injury, up to 42% loss at 6 months after injury. These neuropathological changes suggest that this animal model could serve as a good animal model of neurodegenerative diseases such as AD.
点击下载:
PDF
(896KB)
返 回