Mixed Osteoclastic/Pleomorphic‐Type Giant Cell Tumor of the Pancreas with Ductal AdenocarcinomaHistochemical and Immunohistochemical Study with Review of the Literature
作者:
Mika Watanabe,
Hiroshu Miura,
Hiroko Inoue,
Miwa Uzuki,
Yu Noda,
Naotaka Fujita,
Tadashi Yamazaki,
Takashi Sawai,
期刊:
Pancreas
(OVID Available online 1997)
卷期:
Volume 15,
issue 2
页码: 201-208
ISSN:0885-3177
年代: 1997
出版商: OVID
关键词: Osteoclastic-type giant cell tumor of the pancreas;Pleomorphic-type giant cell carcinoma;Ductal adenocarcinoma;Tartarate-resistant acid phosphatase;Immunohistochemistry
数据来源: OVID
摘要:
We described a rare form of giant cell tumor of the pancreas composed of mixed osteoclastic/pleomorphic-type giant cell tumor with ductal adenocarcinoma. Immunohistochemical study showed positive staining of cytokeratin and epithelial membrane antigen for pleomorphic-type giant cells and ductal adenocarcinoma but negative for osteoclastic-type giant cells. Vimentin stained positive in both types of giant cells but negative in adenocarcinoma. Osteoclastic-type giant cells were strongly positive for CD68 and tartarate-resistant acid phosphatase was present in these cells, suggesting the osteoclast-like character. CD68 was negative for both pleomorphic-type giant cells and ductal adenocarcinoma. From these findings, we consider that this tumor might be a carcinosarcoma-like neoplasm consisting of both an epithelial and a histiocytic-mesenchymal component.
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