Changes in Primidone/Phenobarbitone Ratio During Pregnancy and the Puerperium
作者:
D. Battino,
S. Binelli,
L. Bossi,
M. L. Como,
D. Croci,
C. Cusi,
G. Avanzini,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 1984)
卷期:
Volume 9,
issue 3
页码: 252-260
ISSN:0312-5963
年代: 1984
出版商: ADIS
数据来源: ADIS
摘要:
Plasma concentrations of primidone and its metabolite phenobarbitone were monitored in 9 pregnant epileptic patients treated with primidone (and in 3 cases other antiepileptic drugs) given at constant doses throughout pregnancy and the puerperium. Phenobarbitone plasma concentrations were monitored in another 6 patients given phenobarbitone itself. A trend towards increasing primidone plasma concentrations during the second quarter of pregnancy was evident in all patients, with a concomitant significant decrease in primidone-derived phenobarbitone plasma concentrations. A trend towards a lowering of plasma concentrations of phenobarbitone administered as such was confirmed.These results suggest the usefulness of a careful monitoring of primidone and primidone-derived phenobarbitone during pregnancy and the puerperium. Discrepancies of findings with primidone and phenobarbitone are discussed in view of the possible mechanism involved.
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