Growth Hormone Responses to Sleep, Insulin Hypoglycaemia and Arginine Infusion
作者:
P.S. Ward,
D.C.L. Savage,
期刊:
Hormone Research in Paediatrics
(Karger Available online 1985)
卷期:
Volume 22,
issue 1-2
页码: 7-11
ISSN:1663-2818
年代: 1985
DOI:10.1159/000180065
出版商: S. Karger AG
关键词: Growth hormone;Sleep tests;Stimulation tests
数据来源: Karger
摘要:
This study compares the peak serum growth hormone (GH) concentration during slow wave sleep with the serum GH responses to insulin-induced hypoglycaemia and intravenous arginine infusion in 23 children referred because of short stature (20) or precocious puberty (3). Peak serum GH concentration during sleep correlated significantly with peak GH response to insulin hypoglycaemia (r = 0.64, p < 0.01) and arginine infusion (r = 0.57, p < 0.01). 3 children had subnormal ( < 15 mU/1) peak serum GH concentrations during sleep but normal responses to either insulin-induced hypoglycaemia or intravenous arginine infusion. 1 child had a normal peak serum GH response to sleep but subnormal responses to insulin and arginine. Sleep studies of GH secretion may be indicated when the GH responses to pharmacological stimuli are inconsistent with the observed growth pattern.
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