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HPLC Determination of Beclomethasone Dipropionate and Its Degradation Products in Bulk Drug and Pharmaceutical Formulations

 

作者: D. De Orsi,   L. Gagliardi,   F. Chimenti,   D. Tonelli,  

 

期刊: Analytical Letters  （Taylor Available online 1995）
卷期: Volume 28, issue 9  

页码: 1655-1663

 

ISSN:0003-2719

 

年代: 1995

 

DOI:10.1080/00032719508002772

 

出版商: Taylor & Francis Group

 

关键词: Beclomethasone dipropionate;beclomethasone monopropionates;beclomethasone alcohol;HPLC;analysis in bulk drug and pharmaceuticals

 

数据来源: Taylor

 

摘要:

An HPLC method for the simultaneous determination of beclomethasone dipropionate and its principal degradation products has been developed. The only sample treatment necessary for the analysis is its dilution with methanol. The practical detection limit is 0.02 % of each impurities in terms of the parent drug, whereas the absolute limit of detection is 2.5 ng of each injected compound. The method has been applied to the analysis of both pharmaceutical formulations and samples of bulk drug.

 

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