In this paper we define two concepts of prime ideals for Ω-groups. The first generalizes the definitions of prime ideal in rings, nearrings, Γ-rings, associative algebras and Lie algebras. The second generalizes a concept defined for groups by Ščukin ([21]). We show that both lead to radicals in the sense of Hoehnke ([10]). Furthermore in the case of rings, Γ-rings, abelian zero-symmetric nearrings and cubic rings these two definitions coincide, thus obtaining a new characterization for the prime ideal. Zero-symmetric Ω-groups are defined analogously to the nearring case and a new characterization in term of ideals is given.