Pharmacological aspects of metaldehyde poisoning in mice
作者:
A. M. HOMEIDA,
R. G. COOKE,
期刊:
Journal of Veterinary Pharmacology and Therapeutics
(WILEY Available online 1982)
卷期:
Volume 5,
issue 1
页码: 77-81
ISSN:0140-7783
年代: 1982
DOI:10.1111/j.1365-2885.1982.tb00500.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Metaldehyde, when administered orally to mice at a dose of 1 g kg‐1, produced convulsions and death within 2 h. Brain concentrations of noradrenaline (NA) 5‐hydroxytryptamine (5‐HT) and 5‐hydroxyindoleacetic acid (5‐HIAA) were significantly reduced in these animals relative to controls. Treatment with either intraperitoneal clonidine or diazepam 20 min after administration of metaldehyde reduced the mortality rate and in mice surviving for 5 h, the decrease in brain NA and 5‐HT concentrations were significan
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