Interference with the 5 α-Reductase System
作者:
R. Massa,
L. Martini,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1971)
卷期:
Volume 2,
issue 1-6
页码: 253-270
ISSN:0378-7346
年代: 1971
DOI:10.1159/000301865
出版商: S. Karger AG
关键词: Testosterone;Dihydrotestosterone;Antiandrogens;5α-Reductase;Anterior;Pituitary;Prostate;Progesterone;Corticoids
数据来源: Karger
摘要:
The paper presents evidence indicating that, in an “in vitro” system, progesterone may interfere with the conversion of testosterone into its “active” metabolites (5 alpha-androstan-17 beta-ol-3-one, 5 alpha-androstan-3 beta, 17 beta-diol and 5 alpha-androstan-3 alpha, 17 beta-diol, etc.) both at the anterior pituitary and prostatic levels. Progesterone probably acts as a preferential substrate for the enzyme 5 alpha-reductase present in these structures. Other steroids are also active in diminishing the 5 alpha-reduction of testosterone in its target organs. Both corticoids and progestagens seem to be effective inhibitors for such a reduction. These observations open a new approach for developing anti-androgenic compounds.
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