Short‐term developmental toxicity testing: Considerations in the validation process
作者:
G. L. Kimmel,
期刊:
Teratogenesis, Carcinogenesis, and Mutagenesis
(WILEY Available online 1987)
卷期:
Volume 7,
issue 1
页码: 1-6
ISSN:0270-3211
年代: 1987
DOI:10.1002/tcm.1770070103
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: developmental toxicity;short‐term testing;test validation;risk assessment
数据来源: WILEY
摘要:
AbstractThe development and validation of short‐term tests that assess developmental toxicity have received increased attention due to the large number of agents that need to be tested and the desirability to reduce the overall use of animals in research and safety evaluation. The Short‐Term In Vivo Reproductive Toxicity Test was developed to help meet this need and to provide a method for prioritizing agents for further testing. This report provides a brief overview of the risk assessment process and a focus on the aspects of test validation that should be considered when evaluating short‐term tests. It is intended to give the reader an appreciation for many of the considerations that must go into developing and validating a short‐term test, and to indicate areas within the risk assessment process where inclusion of such a test may be appr
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