Congenital Chloride-Losing Diarrhoea: Absence of the Anion-Exchange Mechanism in the Rectum
作者:
Jenkins H.,
Milla P.,
期刊:
Journal of Pediatric Gastroenterology and Nutrition
(OVID Available online 1997)
卷期:
Volume 24,
issue 5
页码: 518-521
ISSN:0277-2116
年代: 1997
出版商: OVID
关键词: Anion exchange;Bicarbonate;Chloride
数据来源: OVID
摘要:
Background:Congenital chloride-losing diarrhoea is characterized by a defect in chloride/bicarbonate exchange, which is normally present in the ileum and colon. Whether the defect is an absence or a reversal of such an exhange is unclear, and we have investigated two young children with the disorder to answer this question.Methods:We used a previously described nonequilibrium rectal dialysis method, using different dialysate anion concentrations, to investigate the movement of sodium, potassium, chloride, and bicarbonate in the rectum of the two children.Results:The results showed that chloride and bicarbonate movements were not linked in any active way, and both ions appeared to move passively in response to the electrochemical gradients generated.Conclusions:In the two subjects studied, the defect in the rectum appears to be an absence of the normal anion exchange mechanism present in the bowel, rather than its reversal.
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