Tolerance to Ethanol Hypothermia in HOT and COLD Mice
作者:
John C. Crabbe,
期刊:
Alcoholism: Clinical and Experimental Research
(WILEY Available online 1994)
卷期:
Volume 18,
issue 1
页码: 42-46
ISSN:0145-6008
年代: 1994
DOI:10.1111/j.1530-0277.1994.tb00878.x
出版商: Blackwell Publishing Ltd
关键词: Pharmacogenetics;HOT/COLD Selected Lines;Hypothermia;Ethanol;Tolerance;Sensitization
数据来源: WILEY
摘要:
COLD and HOT mice have been selected to be sensitive or resistant, respectively, to the acute hypothermic effect of ethanol. Previous studies have found HOT mice to be relatively resistant to the development of tolerance to this effect, whereas COLD mice readily develop tolerance. By administering several doses of ethanol and recording multiple postdrug temperatures, in the current study we equated the selected lines for area under the curve describing initial hypothermic response over time, a measure reflecting both maximal hypothermia achieved and the duration of total hypothermic response. The dose‐response function for COLD mice was much steeper than that for HOT mice, and HOT mice recovered to baseline body temperatures more slowly. Doses were administered daily for 5 days. Both lines developed tolerance to ethanol hypothermia. The magnitude of tolerance developed was greater in COLD than in HOT mice. At higher doses, HOT mice showed a progressively enhanced hypothermic response over days (i.e., sensitization
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