Current Perspective on the Role of Apoptosis in Atherothrombotic Disease
作者:
Ziad Mallat,
Alain Tedgui,
期刊:
Circulation Research: Journal of the American Heart Association
(OVID Available online 2001)
卷期:
Volume 88,
issue 10
页码: 998-1003
ISSN:0009-7330
年代: 2001
出版商: OVID
关键词: apoptosis;thrombosis;atherosclerosis;acute coronary syndromes
数据来源: OVID
摘要:
Abstract—Thrombus formation on a disrupted atherosclerotic plaque is a threatening event that leads to vessel occlusion and acute ischemia. In this current perspective, we present evidence for apoptosis as a major determinant of the thrombogenicity of the plaque lipid core and a potential contributor to plaque erosion and associated thrombosis. Moreover, apoptosis may directly affect blood thrombogenicity through the release of apoptotic cells and microparticles into the bloodstream.
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