Elution of Anti‐Zwa(‐PlA1) from Autologous Platelets after Normalization of Platelet Count in Post‐Transfusion Purpura
作者:
Ellen Taaning,
Fleming Skov,
期刊:
Vox Sanguinis
(WILEY Available online 1991)
卷期:
Volume 60,
issue 1
页码: 40-44
ISSN:0042-9007
年代: 1991
DOI:10.1111/j.1423-0410.1991.tb00869.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Abstract.In two patients suffering from post‐transfusion purpura, anti‐Zwawas demonstrated in ether eluates from autologous platelets harvested during the remission phase and after normalization of the platelet count. In both patients, platelet‐associated immunoglobulin (PAIg) was demonstrated during the acute phase. PAIg disappeared concomitantly with recovery and, thus, seems to be associated with the thrombocytopenia. These data support the assumption that immunocomplexes are adsorbed nonspecifically to the platelets and cause destruction of autologous platelets lacking the corresponding antigen. An association between the IgG3 subclass of anti‐Zwaantibodies and the destruction of autologous platelets was al
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