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Xmn I Polymorphism in the Gamma-Globin Gene Region among Saudis

 

作者: M.A.F. El-hazmi,  

 

期刊: Human Heredity  （Karger Available online 1989）
卷期: Volume 39, issue 1  

页码: 12-19

 

ISSN:0001-5652

 

年代: 1989

 

DOI:10.1159/000153825

 

出版商: S. Karger AG

 

关键词: Sickle cell disease;Restriction endonucleases;Polymorphism;Saudi Arabia

 

数据来源: Karger

 

摘要:

The γ-globin chains of haemoglobin F are encoded by two non-allelic genes which synthesise two different γ-chains referred to as Gγ and Aγ. Xmn I restricts on both sides of the genes and normally produces an 8.1-kilobase (kb) fragment containing both γ-genes. A polymorphic site on the 5’ end of the Gγ genes has been reported in some populations and it results in the production of a 7.0-kb fragment containing both

 

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