Parenteral agents for hypertension management are commonly required in the ICU. During hypertensive emergencies such as aortic dissection or intracerebral hemorrhage, or in the management of patients with essential hypertension who are not able to take their usual oral medications, parenteral antihypertensives are essential to avoid hypertensive cardiovascular injury. Intravenous agents such as sodium nitroprusside, trimethaphan, and diazoxide have been used for rapid and reliable reduction of BP in the first 24 h in the ICU. Antihypertensive therapy >24 h involves more individualization of therapy, primarily to avoid side-effects.Labetalol has been shown to be an effective parenteral antihypertensive agent, either by iv bolus (1–3) or continuous infusions of < 24 h (4). This report details successful continuous administration of iv labetalol for 6 to 9 days in three patients in a critical care setting. Labetalol should be considered as a therapeutic option in patients who require prolonged iv antihypertensive therapy.